Skin diseases are common in the whole world. In the countries in the process of development, the infectious diseases such as tuberculosis, leprosy and the onchocercose are common, while in the developed countries, inflammatory disorders such as eczema and the acne are common. Disorders of skin can be inherited, for example the syndrome of Ehlers-Danlos, a part of normal development, for example vulgaris of acne, or can present as an element of a systemic disorder, for example the systemic erythematosus of lupus (SLE).
Approximately 25% of the UK population will develop a skin problem and, although self-medication is common, skin disease still accounts for 10% of the workload of family doctors. The common reasons for this are itching or pain, which can interfere with people's ability to function normally or to sleep; rashes which cause anxiety, depression and lack of self-confidence and can lead to social isolation if obviously visible; and an inability to work, because certain dermatoses (such as allergic hand eczema in a builder or hairdresser) can interfere with or even prevent working.
Rarely skin disease can be fatal. Examples are malignant melanoma, toxic epidermal necrolysis and pemphigus.

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